書誌事項
- タイトル別名
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- A case of methotrexate-associated lymphoproliferative disorder associated with oral and skin asynchronous ulcers diagnosed by an oral lesion
- コウコウ ビョウヘン カラ シンダン ニ イタッタ コウコウ ・ ヒフ リョウイキ ノ イジセイ メトトレキサート カンレン リンパ ゾウショクセイ シッカン ノ 1レイ
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説明
<p>Methotrexate (MTX) has been recognized as a first-line treatment for rheumatoid arthritis (RA) because of its ability to reduce the proliferation of innate immune cells. Recently, the occurrence of methotrexate-associated lymphoproliferative disorders (MTX-LPD) in the oral cavity has been reported. We describe a case of MTX-LPD associated with asynchronous ulcers in the oral and skin regions that was diagnosed by oral lesions. A 79-year-old man had been receiving MTX for over 7 years as a treatment for RA. Two years earlier, a skin ulcer had developed in the lumbar region, which histopathologically diagnosed as a sarcoma, and he was treated with heavy-ion radiotherapy. Before he presented to our institution, he had severe bilateral gingival pain in the mandibular molar region for 2 months. The oral lesions appeared to be necrotic ulcers, and a pathological examination revealed lymphocytic infiltration involving atypical cells. Based on the patient's medical history and the results of a histopathological reexamination of the skin lesions, both the oral and skin lesions were diagnosed as MTX-LPD. Although the gingival lesions expanded over the next few weeks, the ulcers spontaneously disappeared after MTX treatment was withdrawn. There have been no signs of recurrence for 2 years.</p>
収録刊行物
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- 日本口腔外科学会雑誌
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日本口腔外科学会雑誌 63 (11), 552-557, 2017
公益社団法人 日本口腔外科学会
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詳細情報 詳細情報について
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- CRID
- 1390282681509281920
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- NII論文ID
- 130006316820
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- NII書誌ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL書誌ID
- 028670807
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDLサーチ
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- CiNii Articles
- OpenAIRE
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- 使用不可