Bone regeneration method using mesenchymal stem cells and PRP complexes in maxillary sinus lift
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- OHYA Morimichi
- Department of Oral and Maxillofacial Surgery, Nagoya University, Graduate School of Medicine
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- YAMADA Yoichi
- Center for Genetic and Regenerative Medicine, Nagoya University, School of Medicine
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- WADA Keisuke
- Department of Oral and Maxillofacial Surgery, Nagoya University, Graduate School of Medicine
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- WATANABE Kazuyo
- Department of Oral and Maxillofacial Surgery, Nagoya University, Graduate School of Medicine
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- OZAWA Ryotaro
- Department of Oral and Maxillofacial Surgery, Nagoya University, Graduate School of Medicine
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- OKAZAKI Yasuhiro
- Department of Oral and Maxillofacial Surgery, Nagoya University, Graduate School of Medicine
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- HIBI Hideharu
- Department of Oral and Maxillofacial Surgery, Nagoya University, Graduate School of Medicine
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- KAGAMI Hideaki
- Department of Tissue Engineering, Nagoya University, Graduate School of Medicine
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- HATA Ken-ichiro
- Center for Genetic and Regenerative Medicine, Nagoya University, School of Medicine
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- UEDA Minoru
- Department of Oral and Maxillofacial Surgery, Nagoya University, Graduate School of Medicine
Bibliographic Information
- Other Title
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- 間葉系幹細胞とＰＲＰ複合体を用いた上顎洞底拳上術における骨造成法の実験的研究
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Abstract
Recently, minimally invasive surgery based on a tissue engineering has become possible. We used an animal model to evaluate a method for bone regeneration by maxillary sinus floor augmentation that uses mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) instead of an autologous bone graft. The MSCs were isolated from rabbit iliac crest marrow aspirates, and PRP was obtained from peripheral blood. MSCs and PRP complexes were used for grafting. In the control group, autogenous particulate cancellous bone and marrow (PCBM) was collected and mixed with PRP. Histological examination showed that new bone formation was good in both groups at 2 and 4 weeks. At 8 weeks, lamellar bone had formed, but fatty marrow was also observed in both groups.<BR>The present results suggest that MSCs/PRP complexes may be used in place of autogenous bone to promote bone regeneration after maxillary sinus floor augmentation.
Journal
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- Japanese Journal of Oral and Maxillofacial Surgery
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Japanese Journal of Oral and Maxillofacial Surgery 50 (10), 559-566, 2004
Japanese Society of Oral and Maxillofacial Surgeons
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Keywords
Details 詳細情報について
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- CRID
- 1390282681509320960
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- NII Article ID
- 10018618920
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- NII Book ID
- AN00189163
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- ISSN
- 21861579
- 00215163
- http://id.crossref.org/issn/00215163
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed