A case of myofibroma arising from the mandible in an adult

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  • MURAMATSU Kyotaro
    The Department of Oral and Maxillofacial Surgery， Tokyo Dental College
  • OOGANE Satoru
    The Department of Oral and Maxillofacial Surgery， Tokyo Dental College
  • WATANABE Akira
    The Department of Oral and Maxillofacial Surgery， Tokyo Dental College
  • YAKUSHIJI Takashi
    The Department of Oral and Maxillofacial Surgery， Tokyo Dental College
  • OOHATA Hitoshi
    The Department of Oral and Maxillofacial Surgery， Tokyo Dental College
  • SHIBAHARA Takahiko
    The Department of Oral and Maxillofacial Surgery， Tokyo Dental College

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  • 成人の下顎骨に発生した筋線維腫の1例
  • セイジン ノ カガクコツ ニ ハッセイ シタ キン センイ シュ ノ 1レイ

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Abstract

Myofibroma is a rare benign nodular tumor arising in soft tissue, bone, or internal organs. We describe an intraosseous myofibroma that occurred in an adult. A 38-year-old woman was referred to our hospital because of mobility of the right mandibular first molar in April 2007. She was aware of mobility of the mandibular molar since 2004. Panoramic radiography demonstrated a well-defined multilocular radiolucent lesion in the mandibular body. Although repeated biopsy examinations were conducted, a definitive diagnosis was difficult, and the lesion was considered a mesodermal tumor. We additionally performed immunohistochemical staining and diagnosed the tumor as a myofibroma. We resected the mandibular tumor from the right mandibular first molar to the right mandibular ramus. Microscopic examination of the surgical specimen revealed dense proliferation of spindle-shaped tumor cells forming fascicles and a pericytomatous pattern with dilated capillaries. A few mitotic figures were observed in the tumor cells, but high cellular atypia was not found. Immunohistochemically, the tumor cells were positive for vimentin and a-SMA and were negative for desmin, S-100, and NFP. There has been no evidence of recurrence as of 5 years after surgery.

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