Correlation between CENP-F mRNA expression and lymph node metastasis in oral squamous cell carcinomas

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  • SHIGEISHI Hideo
    Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
  • MIZUTA Kuniko
    Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
  • HIGASHIKAWA Koichiro
    Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
  • SHIMASUE Hiroshi
    Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
  • OHTA Koji
    Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
  • ONO Shigehiro
    Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
  • SUGIYAMA Masaru
    Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
  • KAMATA Nobuyuki
    Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University

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Other Title
  • 口腔へん平上皮癌におけるＣＥＮＰ‐Ｆの発現とリンパ節転移との関係
  • コウクウ ヘンペイ ジョウヒガン ニ オケル CENP F ノ ハツゲン ト リンパセツ テンイ ト ノ カンケイ

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Expression levels of CENP-F mRNA were investigated in 45 surgically resected oral squamous cell carcinomas (OSCC) and 10 samples of normal gingiva, using real time reverse-transcriptase polymerase chain reaction (RT PCR). The relations between CENP-F mRNA and clinicopathologic variables were studied. The mean expression level of CENP-F mRNA was higher in OSCC tissues than in normal gingiva. There was a significant correlation between the expression level of CENP-F mRNA and lymph node metastasis in the cases of OSCC (p=0.024). These results suggest that OSCC with a high expression level of CENP-F mRNA has high metastatic potential.

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