Adverse events of TS-1 administered to oral cancer patients: Rash associated with a regimen of 2-week treatment followed by a 1-week rest
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- SUZUKI Maiko
- Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
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- YOSHIZAWA Yasumasa
- Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
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- KANAZUKA Ayako
- Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
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- WATANABE Hitoshi
- Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
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- OHASHI Masaru
- Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
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- SHIROTA Tatuo
- Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
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- HATORI Masashi
- Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
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- SHINTANI Satoru
- Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
Bibliographic Information
- Other Title
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- 口腔癌患者におけるTS-1 投与で生じる有害事象の検討 —2週投薬1週休薬によって発現する皮疹を中心に—
- 口腔癌患者におけるTS-1投与で生じる有害事象の検討--2週投薬1週休薬によって発現する皮疹を中心に
- コウクウガン カンジャ ニ オケル TS 1 トウヨ デ ショウジル ユウガイ ジショウ ノ ケントウ 2シュウ トウヤク 1 シュウキュウヤク ニ ヨッテ ハツゲン スル ヒシン オ チュウシン ニ
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Abstract
We evaluated adverse events after administration of TS-1 to patients with oral cancer. The subjects were 29 patients with oral cancer in whom TS-1 was administered as preoperative treatment at our department in 2006 and 2007. Each course of TS-1 (80-120 mg/day)consisted of 14-day drug treatment, followed by a 7-day rest. As adverse events, skin rash occurred in 6 of the 29 patients, oral aphtha, diarrhea, and general malaise in 3 each, pain around the eyeball and myelosuppression in 2 each, and gastric discomfort, oral dryness, taste disorder, and erosion at the angle of the mouth in 1 each. All events were grade as 1 or 2. The incidence of rash has been considered to be lower than that of gastrointestinal disorders or myelosuppression, but was the highest in this study. In 4 of the 6 patients with rash, symptoms improved after the external application of steroids and oral administration of antihistamines and antiallergic drugs, allowing treatment with TS-1 to be continued. Rash occurred early after the start of TS-1 treatment.
Journal
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- Japanese Journal of Oral and Maxillofacial Surgery
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Japanese Journal of Oral and Maxillofacial Surgery 57 (4), 193-198, 2011
Japanese Society of Oral and Maxillofacial Surgeons
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Details 詳細情報について
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- CRID
- 1390282681509817728
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- NII Article ID
- 130004567604
- 10030271744
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- NII Book ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL BIB ID
- 11094654
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed