Periodontal regenerative therapies using cultured autologous gingival and periosteal cell sheets

  • YOSHIE Hiromasa
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences
  • OKUDA Kazuhiro
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences
  • KAWASE Tomoyuki
    Division of Oral Bioengineering, Department of Tissue Regeneration and Reconstitution, Niigata University Graduate School of Medical and Dental Sciences

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Other Title
  • 歯肉細胞シート・骨膜シートを用いた歯周再生治療
  • 第53回総会シンポジウム 口腔外科領域における再生医療,その後の進歩 歯肉細胞シート・骨膜シートを用いた歯周再生治療
  • ダイ53カイ ソウカイ シンポジウム コウクウ ゲカ リョウイキ ニ オケル サイセイ イリョウ ソノゴ ノ シンポ シニク サイボウ シート コツマク シート オ モチイタ シシュウ サイセイ チリョウ

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Based on recent advances in tissue engineering, we have developed three individual therapeuticmethodologies for regeneration of periodontal defects. (1) Human cultured gingival epithelial cell sheets couldbe applied as a promising graft “material" to treatment of chronic desquamative gingivitis. (2) Cultured gingivaldermal substitute could contribute to accelerated recovery of vertical and horizontal gingival recession. (3)Cultured periosteal cell sheets, which are demonstrated to express osteogenic activity in vitro and in vivo animalstudies, could regenerate alveolar bone defects in combination with platelet-rich plasma and porous hydroxapatiteparticles. Finally, current and next-generation technology in tissue engineering and periodontal regenerative medicineshould be discussed.

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