A case of dedifferentiated carcinoma occurring in adenoid cystic carcinoma of the submandibular gland

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  • RI Shinsho
    Department of Oral and Maxillofacial Surgery, Kakogawa East City Hospital
  • SHIGETA Takashi
    Department of Oral and Maxillofacial Surgery, Kakogawa East City Hospital Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine
  • HASEGAWA Takumi
    Department of Oral and Maxillofacial Surgery, Kakogawa East City Hospital Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine
  • TAKATA Naoki
    Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine
  • YOSHITAKE Masaru
    Department of Oral and Maxillofacial Surgery, Kakogawa East City Hospital
  • KOMORI Takahide
    Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine

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Other Title
  • 顎下腺原発脱分化型腺様嚢胞癌の1例
  • ガク カセン ゲンパツ ダツブンカガタセン ヨウノウホウガン ノ 1レイ

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Dedifferentiated carcinoma is defined as the abrupt transformation of a low-grade, well-differentiated tumor into a tumor of high malignancy. Because the transformed cells are highly aggressive, recurrence and metastasis frequently occur.<br>We report a case of dedifferentiated carcinoma in adenoid cystic carcinoma of the submandibular gland with multiple metastases to the cervical lymph nodes and distant metastasis to the ileum.<br>A 73-year-old woman was referred to our hospital because of submandibular gland carcinoma with multiple lymph node metastases. In another clinic, adenocarcinoma was pathologically diagnosed on lymph node biopsy. A surgically resected specimen showed that the tumor was composed of both a cribriform pattern of conventional low-grade adenoid cystic carcinoma and a high-grade dedifferentiated carcinoma. The lesion was thus a dedifferentiated carcinoma. Lymph node metastases contained dedifferentiated components. One year and a half after the operation, the tumor metastasized to the small intestine (ileum) . The tumor in the ileum was also pathologically diagnosed as a high-grade dedifferentiated carcinoma.

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