口腔に発生した腺扁平上皮癌の2例

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  • Two cases of adenosquamous cell carcinoma in the oral cavity
  • コウコウ ニ ハッセイ シタ セン ヘンペイ ジョウヒガン ノ 2レイ

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Adenosquamous cell carcinoma (ASC) is a rare tumor containing components of both adenocarcinoma and squamous cell carcinoma. It is often associated with lymph node and distant metastases, and is known to be among the most highly malignant tumors. There is no well-established treatment strategy for ASC yet because of the limited number of cases reported; therefore, evidence, particularly for the efficacy of non-surgical treatment, is being sought. We report the clinical features of two patients with ASC. Patient 1 was a 70-year-old man with ASC of the floor of the mouth (left side). The patient underwent by surgery, with a favorable postsurgical outcome, although he died of another disease 3 years after surgery. Petient 2 was a 48-year-old man with ASC of the left upper jaw associated with intracranial involvement. Although surgery was not performed, a complete response was obtained by radiotherapy (66 Gy) and two courses of chemotherapy (docetaxel at 60 mg/m2 on day 1, cisplatin at 60 mg/m2 on day 1, and 5-fluorouracil at 600 mg/m2 on days 1-5). However, the cancer recurred 10 months after the completion of chemoradiotherapy, and the patient died 18 months later. Surgery is currently recommended as the treatment of choice for ASC. Our experience with these cases suggests that survival may be prolonged by surgery combined with chemoradiotherapy.

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