A case of hereditary gingival fibromatosis with long-term follow-up after gingivectomy

DOI Web Site 17 References
  • KIMURA Masashi
    Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry Department of Oral and Maxillofacial Surgery, Yokkaichi Municipal Hospital
  • MACHIDA Junichiro
    Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry Department of Oral and Maxillofacial Surgery, Toyota Memorial Hospital
  • YAMAGUCHI Seishi
    Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry
  • SHIBATA Akio
    Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry
  • KOMAKI Kanji
    Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry Department of Oral and Maxillofacial Surgery, Yokkaichi Municipal Hospital
  • SHIMOZATO Kazuo
    Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry

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Other Title
  • 歯肉切除後に長期経過観察を行った遺伝性歯肉線維腫症の1例
  • シニク セツジョ ゴ ニ チョウキ ケイカ カンサツ オ オコナッタ イデンセイ シニク センイ シュショウ ノ 1レイ

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Hereditary gingival fibromatosis (HGF) is a rare autosomal dominant disorder characterized by slowly progressive fibrous overgrowth of the gingiva. We report the clinical results of long-term follow-up after gingivectomy in a patient with HGF. A 13-year-old boy was referred to our hospital because of gingival overgrowth. The upper and lower gingiva were severely overgrown. The primary dentition was initially affected, and generalized gum overgrowth caused unerupted permanent teeth. There was no sign of syndrome. His father and two sisters had a similar gingival condition. On the basis of these findings, we diagnosed the lesion as a hereditary gingival overgrowth. A gingivectomy was carried out with the patient under local anesthesia, and there was no recurrence after surgery. Recently, son of sevenless-1 (SOS1) has been reported as a responsible gene for HGF. However, no mutation in SOS1 gene was found in this family.

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