De novo design of pseudoproteins equipped with one of a diversity of functional groups.

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  • NISHINO Norikazu
    Department of Applied Chemistry, Faculty of Engineering, Kyushu Institute of Technology

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  • 機能性原子団を装置した擬タンパク質のディノボ設計
  • キノウセイ ゲンシダン オ ソウチシタ ギタンパクシツ ノ ディノボ セッケイ

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Abstract

A pair of pyrene groups formed an excimer due to the arrangement in close proximity within a designed four-α-helix bundle structure. At the same position were incorporated a pair of flavin moieties. The oxidative activity wellworked against1-alkyldihydronicotinamide in the presence of surfactants.A porphyrin ring was also incorporated to a two-α-helix peptide. The conjugate formed a dimetic four-α-helix bundle structure with a face-to-face porphyrin arrangement. Incorporation of Fe (III) to the conjugate gave an artificial peroxidase. These pseudoproteins may evolve for artificial functions by adequate incorporation of various catalytic and photoreactive groups.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 37 (4), 161-164, 1997

    The Biophysical Society of Japan General Incorporated Association

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