A case of nodular fasciitis of the tongue

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  • SUKA Noriyuki
    Division of Oral and Maxillofacial Surgery Ⅱ, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • TANAKA Akio
    Division of Oral and Maxillofacial Surgery Ⅱ, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • MAGOSHI Seishi
    Division of Oral and Maxillofacial Surgery Ⅱ, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • SUZUKI Seiji
    Division of Oral and Maxillofacial Surgery Ⅱ, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • KUSAMA Kaoru
    Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • SAKASHITA Hideaki
    Division of Oral and Maxillofacial Surgery Ⅱ, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry

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Other Title
  • 舌に発生した結節性筋膜炎の1例
  • シタ ニ ハッセイ シタ ケッセツセイキン マクエン ノ 1レイ

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Abstract

Nodular fasciitis is a pseudosarcomatous reactive lesion of fibroblasts/myofibroblasts. It usually develops in the subcutaneous fascia of the extremities and trunk, but rarely arises in the oral mucosal soft tissue.<br>We report a case of nodular fasciitis of the tongue in a 34-year-old man. Intraoral examination revealed a 3-mm, elastic, soft nodular tumor of the dorsum of the tongue. Histopathologic examination showed a diffuse, infiltrative proliferation of plump spindle cells in the submucosa. These cells were immunopositive for vimentin, and negative for α-smooth muscle actin, HHF-35, S-100 protein, and CD34. The Ki-67 labeling index was high, with an average of 19.8 %. Ultrastructurally, spindle cells showed a fibroblastic phenotype with occasional myofibroblastic differentiation. Recurrence was not evident 14 months after simple excision.

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