口底部MALTリンパ腫から生じたびまん性リンパ腫の1例

  • 馬越 誠之
    明海大学歯学部病態診断治療学講座口腔顎顔面外科学分野
  • 福田 正勝
    明海大学歯学部病態診断治療学講座口腔顎顔面外科学分野
  • 南 弘子
    明海大学歯学部病態診断治療学講座口腔顎顔面外科学分野
  • 鈴木 正二
    明海大学歯学部病態診断治療学講座口腔顎顔面外科学分野
  • 草間 薫
    明海大学歯学部病態診断治療学講座病理学分野
  • 坂下 英明
    明海大学歯学部病態診断治療学講座口腔顎顔面外科学分野

書誌事項

タイトル別名
  • A case of diffuse lymphoma arising from MALT lymphoma in the oral floor
  • クチ テイブ MALT リンパ シュ カラ ショウジタ ビマンセイ リンパ シュ ノ 1レイ

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抄録

We describe a case of malignant lymphoma located in the oral floor of a 72-year-old man. The patient noticed a painless mass in the oral floor, which enlarged slowly over the course of several weeks. He was referred to our department. An elastic, painless, hard tumor, 28×12mm, was located in the right side of the oral floor. Magnetic resonance imaging (T1) showed enhancement of a mass. Gallium scintigraphy showed positive results in the oral floor, but negative results for the other region. A biopsy was performed, and the pathological diagnosis was a suspected MALT lymphoma with a lymphoepithelial lesion in the oral floor.<BR>Tumor resection, including both sublingual glands and the upper layer of the mylohyoid muscle, was performed under general anesthesia.<BR>Histopathological examination revealed diffuse, nodular proliferation of large atypical lymphoid cells with round or indented nuclei and distinct nucleoli. In addition to foci of diffuse proliferations of medium-sized lymphoid cells, lymphoepithelial lesions were present. Immunohistochemical examinations revealed that the atypical cells were positive for CD20, 79a, CD45RO, and Bcl-2, but were negative for CD 10 and Helicobacter pylori. This case was finally diagnosed as a diffuse large B cell lymphoma arising from MALT lymphoma.

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