Induced Raft Domains Working as a Platform for Digital Signal Transduction

DOI Web Site Web Site 22 References
  • SUZUKI Kenichi G. N.
    Institute for Integrated Cell-Material Sciences (iCeMS), Institute for Frontier Medical Sciences, Kyoto University The Dynamic Mechanism of and Fundamental Technology for Biological System, Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science & Technology Agency (JST)
  • KUSUMI Akihiro
    Institute for Integrated Cell-Material Sciences (iCeMS), Institute for Frontier Medical Sciences, Kyoto University Membrane Mechanism Project, International Cooperative Research Project (ICORP), Japan Science & Technology Agency (JST)

Bibliographic Information

Other Title
  • ディジタルシグナル変換場としてはたらく誘導ラフトドメイン
  • ディジタル シグナル ヘンカンバ ト シテ ハタラク ユウドウ ラフト ドメイン

Search this article

Abstract

Hypothetical membrane domains, called lipid raft domains, have been investigated, using single-molecule tracking. Such domains are formed on-demand upon stimulation-induced clustering of raft-associable receptors. Furthermore, signaling molecules are recruited to such induced rafts transiently (of the order of 0.1 s). Therefore, we propose that raft-related bulk intracellular signals that tend to last over 1000 s might be pulse coded or frequency modulated by the pulse-like digital activation of individual molecules, and that the intensity of the bulk signal might mainly be determined by the number of pulses at a given time.<br>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 48 (6), 320-324, 2008

    The Biophysical Society of Japan General Incorporated Association

References(22)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top