Can Lipid Rafts be Explained Thermodynamically?—Solid/Liquid Phase Diagram for Incongruent Melting and Cluster Formation—

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  • TAMAI Nobutake
    Department of Life System, Institute of Technology and Science, The University of Tokushima
  • GOTO Masaki
    Department of Life System, Institute of Technology and Science, The University of Tokushima
  • MATSUKI Hitoshi
    Department of Life System, Institute of Technology and Science, The University of Tokushima

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Other Title
  • 脂質ラフトは熱力学的に説明できるのか？―非調和融点型固液相図とクラスター形成―
  • シシツ ラフト ワ ネツ リキガクテキ ニ セツメイ デキル ノ カ? : ヒチョウワ ユウテンガタコエキソウズ ト クラスター ケイセイ
  • 「特異性」―初心に還る―

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Description

We have recently studied the thermotropic phase behavior of cholesterol-containing binary bilayers of a homologous series of linear saturated phosphatidylcholines (CnPCs) with different hydrocarbon-chain lengths n (n = 14-18) using the Prodan fluorescence spectroscopy and differential scanning calorimetry to construct temperature-composition phase diagrams for those binary bilayers. This review describes our concept on the miscibility between cholesterol and CnPC on the basis of the experimental phase diagrams as well as the distribution of cholesterol within the bilayers derived by applying the so-called superlattice model.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 54 (3), 154-157, 2014

    The Biophysical Society of Japan General Incorporated Association

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