Traffic Flow and Translation Process

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  • 交通流と翻訳過程
  • コウツウリュウ ト ホンヤク カテイ

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Abstract

Messenger RNAs (mRNA), that code sequences of amino acids by using triplets of nucleotides (codons), are translated by multiple ribosomes. Usually more than one codon corresponds to an amino acid. The ribosome speed is known to dependent on the codon, thus there is a room to keep an amino acid sequence (protein) and change the ribosome speed. We model the ribosome traffic with codon-dependent rate estimated for E. coli and show that some wild type codon sequences can regulate “traffic jam” by placing slow codons at the begging of the mRNA. We discuss possible roles of slow codons in translation process.<br>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 53 (1), 015-019, 2013

    The Biophysical Society of Japan General Incorporated Association

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