Structure and Function of Hemoglobin

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  • MAKINO Nobuo
    Division of Biochemistry, Tsukuba University School of Medicine

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Other Title
  • ヘモシアニンの構造と機能
  • ヘモシアニン ノ コウゾウ ト キノウ

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Description

Recent advances in the study of hemocyanin (Hc) are reviewed briefly.<BR>Although subunit structues of molluscan and arthropodous Hc have been analyzed extensively by electron microscopic and ultracentrifugal techniques, the nature of cooperative interactions between the subunits is not well known yet. Ligand binding properties of Hc are described by the cooperativity model of Monod-Wyman-Changeux, though considerable modifications of the model are needed to fit experimental data.<BR>The binuclear cuprous structure of active site of Hc has been established recently by physicochemical methods such as electron paramagnetic resonance and resonance Raman spectroscopy. N atoms are suggested as ligands of the cuprous ions.<BR>Crystallographic studies of Hc are being attempted, and it will give informations about the structure of "copper pocket" of Hc.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 19 (4), 171-175, 1979

    The Biophysical Society of Japan General Incorporated Association

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