Stoichiometry and Modulation of Cardiac Voltage-Gated Ion Channels

DOI Web Site Web Site 1 Citations 33 References
  • NAKAJO Koichi
    Division of Biophysics and Neurobiology, National Institute for Physiological Sciences Department of Physiological Sciences, Graduate University of Advanced Sciences
  • KUBO Yoshihiro
    Division of Biophysics and Neurobiology, National Institute for Physiological Sciences Department of Physiological Sciences, Graduate University of Advanced Sciences

Bibliographic Information

Other Title
  • 電位依存性カリウムチャネルKCNQ1の複合体ストイキオメトリーと機能制御機構
  • デンイ イソンセイ カリウムチャネル KCNQ1 ノ フクゴウタイ ストイキオメトリー ト キノウ セイギョ キコウ

Search this article

Abstract

KCNQ1 channel is a cardiac voltage-gated potassium channel. KCNQ1 forms an ion channel complex with auxiliary subunit KCNE proteins. KCNE proteins dramatically change KCNQ1 gating, for example, KCNE1 slows the activation kinetics of KCNQ1 channels 100-times slower. The mechanisms how KCNE1 proteins modify KCNQ1 channel gating have been central questions yet to be answered. Here we review recent findings regarding the structure-function relationships of KCNQ1/KCNE1 complex, including the stoichiometry and the functional interactions between the subunits, and discuss how KCNE1 proteins modify the gating of KCNQ1 channels.<br>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 53 (6), 313-316, 2013

    The Biophysical Society of Japan General Incorporated Association

Citations (1)*help

See more

References(33)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top