脂質平面膜法によるイオンチャネルの再構成

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書誌事項

タイトル別名
  • Ion channel reconstitution in planar lipid bilayers
  • シシツ ヘイメン マク ホウ ニ ヨル イオン チャネル ノ サイ コウセイ
  • Fusion method and electrophysiological analysis of channel structure
  • 融合法の実際と電気生理学的構造解析

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抄録

In recent years various ionic channels have been reconstituted in planar lipid bilayers by which rigorous analysis of the electrical behavior of single ionic channels can be made. I have reviewed, in the first half of this article, practical techniques for forming planar bilayers and for incorporating channels into them. The second half deals with a structural analysis of the ion conducting pathway of the reconstituted K+ channel from sarcoplasmic reticulum solely by measuring its electrical properties. The electrical analysis of channel structure should be a promissing approach to bridge the gap between the electrical property and the molecular structure of channel proteins in lipid bilayers.

収録刊行物

  • 生物物理

    生物物理 27 (4), a149-a158, 1987

    一般社団法人 日本生物物理学会

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