Mitochondrial Dynamics and Cellular Antiviral Immunity

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  • KOSHIBA Takumi
    Department of Biology, Faculty of Sciences, Kyushu University The Graduate School of Systems Life Sciences, Kyushu University
  • KUBOYAMA Misa
    The Graduate School of Systems Life Sciences, Kyushu University

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  • 細胞内におけるミトコンドリアの形態調節ならびに抗ウイルス免疫応答
  • サイボウ ナイ ニ オケル ミトコンドリア ノ ケイタイ チョウセツ ナラビニ コウウイルス メンエキ オウトウ

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Abstract

Mitochondria, dynamic organelles that undergo continuous cycles of fusion and fission events, are believed to play an important role in controlling organelle morphology, copy number, mitochondrial DNA maintenance and are also involved in cellular innate antiviral immunity. In mammals, mitochondrial dynamics rely on high molecular weight GTPases, mitofusin (Mfn1 and Mfn2), OPA1, and Drp1. Recently our studies revealed that Mfn2, a mediator of mitochondrial fusion, acts as an inhibitor of mitochondria-mediated antiviral immunity, which leads us to a linkage between mitochondrial dynamics and antiviral immunity in mammals. In this review, we discuss the participation of mitochondrial dynamics in antiviral immune responses and also show the evidence that the physiological function of mitochondria plays a key role in innate antiviral immunity.<br>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 51 (4), 174-177, 2011

    The Biophysical Society of Japan General Incorporated Association

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