書誌事項
- タイトル別名
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- Rolling Circle Translation of Circular RNA
- カンジョウ RNA オ モチイタ ローリングサークルガタ ホンヤク ハンノウ
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抄録
<p>In an E. coli cell-free translation system, we found that a circular RNA containing an infinite open reading frame produced more translation product than its linear counterpart by two orders of magnitude, because a ribosome can work more effectively towards the elongation on circular RNA than it can on linear RNA. We then tested circular RNAs containing an infinite open reading frame could be translated in eukaryotic systems, in the absence of any particular element for internal ribosome entry, a poly-A tail, or a cap structure. We found that the circular RNAs also produced long peptides in eukaryotic translation systems, possibly owing to the rolling circle amplification mechanism.</p>
収録刊行物
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- 生物物理
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生物物理 57 (1), 005-010, 2017
一般社団法人 日本生物物理学会
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詳細情報 詳細情報について
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- CRID
- 1390282681511529600
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- NII論文ID
- 130005296471
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- NII書誌ID
- AN00129693
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- ISSN
- 13474219
- 05824052
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- NDL書誌ID
- 028180660
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可