Mechanism of "NBD engine" in an ABC transporter, CFTR channel

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  • SOHMA Yoshiro
    Department of Pharmacology and Neuroscience, Keio University Medical School John M Dalton Cardiovascular Research Center, University of Missouri-Columbia
  • HWANG Tzyh-Chang
    Department of Medical Pharmacology and Physiology, School of Medicine, John M Dalton Cardiovascular Research Center, University of Missouri-Columbia

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Other Title
  • ＡＢＣトランスポータ・ＣＦＴＲチャネルにおけるＮＢＤエンジンの動作メカニズム
  • ABC トランスポータ CFTR チャネル ニ オケル NBD エンジン ノ ドウサ メカニズム

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Description

The cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ATP-binding cassette (ABC) transporter superfamily, is an anion channel which plays an important fundamental role in fluid and electrolyte transport across epithelial tissues. In the most of ABC transporters, two highly-conserved nucleotide-binding domains (NBDs) form a common engine that utilizes the energy of ATP hydrolysis to active-transport a wide spectrum of substrates. In CFTR, the ATP-dependent “NBD engine” drives the gate of the ion conducting pore by cycles of ATP binding and hydrolysis. In this review, we introduce the recent advances in the studies for the molecular mechanism of ATP-dependent NBD engine in CFTR channels.<br>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 50 (5), 228-231, 2010

    The Biophysical Society of Japan General Incorporated Association

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