Structure and Function of Two Prostaglandin (PG) Synthases for Drug Design

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  • 阻害剤開発のための２種のプロスタグランジン合成酵素の構造と機能
  • ソガイザイ カイハツ ノ タメ ノ 2シュ ノ プロスタグランジン ゴウセイ コウソ ノ コウゾウ ト キノウ

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Abstract

The structural based drug-design (SBDD) is one of the useful methods for producing a novel medicine. We recently succeeded in X-ray crystallographic determination of two target molecules. One is human hematopoietic prostaglandin (PG) D synthase (H-PGDS) that produces PGD2 as an allergic mediator in mast cells and Th2 cells. The other is Trypanosoma brucei PGF2α synthase (TbPGFS), a member of the aldo-ketoreductase superfamily, catalyzes the NADPH-dependent reduction of PGH2 to PGF2α, whose overproduction during trypanosomiasis causes miscarriage in infected female subjects. In this report, we introduce the recent progress in the research of the high resolution structures of human H-PGDS and TbPGFS useful for SBDD.<br>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 47 (1), 036-043, 2007

    The Biophysical Society of Japan General Incorporated Association

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