書誌事項
- タイトル別名
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- Structure and Dynamics of Membrane-embedded KcsA Potassium Channel Revealed by Atomic Force Microscopy
- マク ナイ KcsA カリウムチャネル ノ ゲンシ カンリョク ケンビキョウ ニ ヨル コウゾウ ト ドウタイ カイセキ
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抄録
The KcsA channel is a prototypical potassium channel, exhibiting pH-dependent gating. The structure of the transmembrane pore-domain of the KcsA channel was examined using atomic force microscopy (AFM) under the membrane-embedded condition. In the closed conformation, the cytoplasmic end of the pore domain was protruded from the membrane surface. In the open conformation, the open pore at the center of the tetrameric channel was resolved, and the protrusion was substantially shortened relative to the closed conformation. High-speed AFM revealed the clustering–dispersion dynamics upon pH changes, and this collective behavior was closely related to the gating conformational changes.
収録刊行物
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- 生物物理
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生物物理 55 (1), 005-010, 2015
一般社団法人 日本生物物理学会
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詳細情報 詳細情報について
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- CRID
- 1390282681512733184
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- NII論文ID
- 130004794734
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- NII書誌ID
- AN00129693
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- ISSN
- 13474219
- 05824052
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- NDL書誌ID
- 026094831
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可