Subunit Interaction on Ligand Binding of Hemoglobin

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  • SUGITA Yoshiki
    Department of Biochemistry, Kanazawa University, School of Medicine

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Other Title
  • ヘモグロビンのリガンド結合とサブユニット間相互作用
  • ヘモグロビン ノ リガンド ケツゴウ ト サブユニット カン ソウゴ サヨウ

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Description

The Preutz model for the cooperative ligand binding and the interactions between hemoglobin subunits is briefly described. Several results are presented indicating that the binding of the ligand or changes of spin states of the irons at some hemes of a tetramer alter the states of the other hemes as detected by spectrophotometry. ESR and NMR, which support the Perutz model. The importance of describing the difference in the states of deoxygenated hemes between totally deoxygenated Hb and the intermediates in ligand binding is stressed. Kinetic results suggestingsting the presence of the intermediate states and the kinetic parameters for half liganded tetramers are introduced.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 14 (1), 27-35, 1974

    The Biophysical Society of Japan General Incorporated Association

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