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- SAKABE Noriyoshi
- Department of Chemistry Faculty of Science, Nagoya University
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- SAKABE Kiwako
- Department of Chemistry Faculty of Science, Nagoya University
Bibliographic Information
- Other Title
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- インスリンの構造
- インスリン ノ コウゾウ
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Description
This review contains the historical development on the insulin structure study which was begun in 1935 by D.C. Hodgkin, and the relationship between the structure and the biological activity. As 2 Zn insulin crystals belong to space group R3 and the positions of the main heavy atom in the most derivatives are very close to the three fold axis, many difficalties had to be overcome during the structure determination. We describe the three dimensional arrangement of atoms in the molecule in 2 Zn insulin crystal and particularly its states of aggregation. The binding site of insulin receptor is proposed on the basis of the three dimensional structure, biochemical studies, and the studies using modified insulin, and the structure of proinsulin is also mentioned.
Journal
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- Seibutsu Butsuri
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Seibutsu Butsuri 15 (6), 310-328, 1975
The Biophysical Society of Japan General Incorporated Association
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Details 詳細情報について
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- CRID
- 1390282681513000064
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- NII Article ID
- 130000723290
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- NII Book ID
- AN00129693
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- ISSN
- 13474219
- 05824052
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- NDL BIB ID
- 1687812
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed