イオンchannelの親和性とgating機構の状態の示標

北里 宏

doi:10.2142/biophys.15.75

イオンchannelの親和性とgating機構の状態の示標

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北里宏

京都府立医大第二生理

書誌事項

タイトル別名

A measure of the state of the gate controlling system in the excitable membrane
イオン chanel ノシンワセイト gating キコウノジョウタイ

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説明

A theoretical relation between permeability and the affinity of channels specific for the questioned ion species was derived in terms of the fluid mosaic model. It was mentioned that, when the affinity of channels to the permeable ion was not extremely high, the dependence of the chord conductance on membrance potential did not correctly represent the dependecne of the number of the conducting channels on membrane potential. Analyses of the relation of K permeability to [K]₀ in Nitella and myelinated nerve fibres revealed that the affinity of K channels was independent of membrane potential, and neither so high that all the conducting channels were occupied by K⁺, nor so low that only a negligible fraction of the channels was occupied. Under such conditions, the actual relation of the number of open K channels to membrane potential may be estimated from the modified g_K vs. E relation obtained by using the instantaneous current voltage relation.