Slow trangent plase observed in time course of enzyme-calalyzed reaction

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  • 酵素反応にあらわれる遅い遷移相
  • コウソ ハンノウ ニ アラワレル オソイ センイソウ

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Description

The present review deals with slow trangent phenomena in the enzyme reaction accompanied by time lag or burst phase in a range of time scale from several minutes to one second in the initial time course: the observation of these phases may not require any special techniques for rapid reaction measurement.<BR>The phenomenon is often observed in oligomeric regulatory enzymes rather than in monomeric enzymes.<BR>The phenomenon may involve a slow conversion of one form of the enzyme to a different form (s) with different activity. The reaction mechanism illustrating such phenomenon is discuseed in connection with cooperativity (sigmoidal relation between steady-state rate and ligand concentration). In addition, monomeric enzyme reactions with slow trangent phases and enzyme reactions with the trangents causing in ligand side but not in the enzyme are also reviewed.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 15 (1), 23-29, 1975

    The Biophysical Society of Japan General Incorporated Association

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