チロシン代謝に及ぼすニコチン酸とトリプトファンの影響

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書誌事項

タイトル別名
  • Effects of Nicotinic Acid and Tryptophan on Tyrosine Metabolism
  • チロシン タイシャ ニ オヨボス ニコチンサン ト トリプトファン ノ エイキ

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説明

In the nicotinic acid supplemented rats, the uptake of 14C-tyrosine into brain was lower than that of the nicotinic acid deficient rats at 2 hours after the administration of 14C-tyrosine. The causes of decrease in the uptake of 14C-tyrosine into the brain by the administration of nicotinic acid to the nicotinic acid deficient rats was described in this paper.<br>(1) The nicotinic acid deficient rats converted 14C-tyrosine more slowly to 14CO2 than the nicotinic acid supplemented rats. And the disappearance of 14C-tyrosine from serum was rapid by the administration of nicotinic acid to the nicotinic acid deficient rats.<br>(2) Nicotinic acid caused no change in tyrosine concentrations in the liver. Therefore, increased production of labeled CO2 by the administration of nicotinic acid did not affect the dilution of the labeled tyrosine by cold tyrosine.<br>(3) Tyrosine transaminase activity observed in the nicotinic acid deficient rats was lower than that of the nicotinic acid supplemented rats.<br>Therefore, the increased activity of tyrosine transaminase in liver and the increased turnover of 14C-tyrosine in the body after the administration of nicotinic acid to the nicotinic acid deficient rats decreased the uptake of 14C-tyrosine into the brain.

収録刊行物

  • 栄養学雑誌

    栄養学雑誌 36 (2), 61-68, 1978

    特定非営利活動法人 日本栄養改善学会

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