雄ラットの生殖器官成熟に及ぼすトコフェロール誘導体の影響

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タイトル別名
  • Effects of Tocopherol Derivatives on Maturation of Reproduction Organs on Male Rats.
  • オス ラット ノ セイショク キカン セイジュク ニ オヨボス トコフェロール

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Derivatives, dl-α-tocopheryl acrylate and dl-α-tocopheryl crotonate, were orally administered for 45 consecutive days to rats kept in a dark room. The distribution of tocopherol in the tissues, protein, RNA and DNA levels in the testis, polyamine concentrations in the testis and prostate were measured.<br>Levels of lutenizing hormone (LH) and folliclestimulating hormone (FSH) in the pituitary and serum as well as that of testosterone in the testis were also measured.<br>When everyone of the two kinds of tocopherol derivatives was consecutively given to rats, both the accumulation of tocopherol and concentration of polyamine in the testis were increased compared to the case where dl-α-tocopherol was alone administered. A significant increase of polyamine concentration in the prostate as well as an increase of the testicular levels of RNA, protein and testosterone suggest a possible correlation with the accumulation of tocopherol in the testis. On the other hand, testosterone synthesis may be inhibited by dl-α-tocopheryl crotonate since it decreased polyamine in the prostate and that of testosterone in the testis.

収録刊行物

  • 栄養学雑誌

    栄養学雑誌 50 (2), 79-85, 1992

    特定非営利活動法人 日本栄養改善学会

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