Effects of Tocopherol Derivatives on Maturation of Reproduction Organs on Male Rats.

DOI Web Site
  • Koremura Naohisa
    Department of Science Information, Tokyo University of Agriculture
  • Hasegawa Tadao
    Department of Agricultural Chemistry, Tokyo University of Agriculture
  • Suzuki Takao
    Department of Agricultural Chemistry, Tokyo University of Agriculture

Bibliographic Information

Other Title
  • 雄ラットの生殖器官成熟に及ぼすトコフェロール誘導体の影響
  • オス ラット ノ セイショク キカン セイジュク ニ オヨボス トコフェロール

Search this article

Abstract

Derivatives, dl-α-tocopheryl acrylate and dl-α-tocopheryl crotonate, were orally administered for 45 consecutive days to rats kept in a dark room. The distribution of tocopherol in the tissues, protein, RNA and DNA levels in the testis, polyamine concentrations in the testis and prostate were measured.<br>Levels of lutenizing hormone (LH) and folliclestimulating hormone (FSH) in the pituitary and serum as well as that of testosterone in the testis were also measured.<br>When everyone of the two kinds of tocopherol derivatives was consecutively given to rats, both the accumulation of tocopherol and concentration of polyamine in the testis were increased compared to the case where dl-α-tocopherol was alone administered. A significant increase of polyamine concentration in the prostate as well as an increase of the testicular levels of RNA, protein and testosterone suggest a possible correlation with the accumulation of tocopherol in the testis. On the other hand, testosterone synthesis may be inhibited by dl-α-tocopheryl crotonate since it decreased polyamine in the prostate and that of testosterone in the testis.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top