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Effect of Hot-Spring Hydrotherapy on Lymphocyte Subsets Expressing β<sub>2</sub>-Adrenergic Receptors
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- SAKUMA Masahiro
- Department of Fundamental Research for Complementary and Alternative Medicine, Kanazawa Medical University
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- MATSUBA Shintaro
- Department of Fundamental Research for Complementary and Alternative Medicine, Kanazawa Medical University
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- MATSUNO Hideo
- First Department of Otorhinolaryngology, School of Medicine, Toho University
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- UCHIKAWA Kumiko
- Ishikawa Natural Medicinal Products Research Center
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- ITOU Tohru
- Endoscopy Department Office, Kanazawa Medical University Hospital
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- SHIMIZU Shouji
- Department of Fundamental Research for Complementary and Alternative Medicine, Kanazawa Medical University
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- YAMAGUCHI Nobuo
- Department of Fundamental Research for Complementary and Alternative Medicine, Kanazawa Medical University Ishikawa Natural Medicinal Products Research Center
Bibliographic Information
- Other Title
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- 短期温泉浴の β<sub>2</sub>-アドレナリン受容体発現リンパ球サブセットへの影響
- 短期温泉浴のβ2-アドレナリン受容体発現リンパ球サブセットへの影響
- タンキ オンセンヨク ノ ベータ 2 アドレナリン ジュヨウタイ ハツゲン リンパキュウ サブセット エ ノ エイキョウ
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Description
We have previously reported that hot-spring hydrotherapy for a short duration can change hormone levels in the blood and quantitatively as well as qualitatively regulate leukocytes and their subpopulations. In this study, we examined the effect of hot-spring hydrotherapy on the lymphocytes expressing β2-adrenergic receptors (β2-ARs). We obtained peripheral blood from 9 healthy volunteers (age, 49.7±11.2 years) at the same sampling time before and after (the next day) hot-spring hydrotherapy, and measured the total and differential leukocyte counts and the levels of 3 catecholamines (adrenaline, noradrenaline, and dopamine). We also analyzed the β2-AR of lymphocyte subsets by combination with fluorescent monoclonal antibodies (CD3, CD4, CD 8, CD 19, and CD56) by using flow cytometry.<br> The number of granulocytes significantly decreased after hot-spring hydrotherapy (p < 0.05). The ratio of β2-AR+ CD4+ cells and β2-AR+ CD3+ cells was low, but that of β2-AR+ CD56+ cells and β2-AR+ CD8+ cells was high. The CD8+ cell and CD56+ cell counts tended to increase after hot-spring hydrotherapy, but no significant variation was found in the β2-AR+ cells of each subset. Adrenaline levels also significantly decreased after hot-spring hydrotherapy (p < 0.05). The rate of change in adrenaline levels before and after hot-spring hydrotherapy was highly correlated with the rate of change in the levels of CD56+, CD8+, and β2-AR+ CD56+ cells. Thus, we found a difference in thepercentage of β2-AR-expressing cells in the lymphocyte subsets. Therefore, it is possible that a short duration of hot-spring hydrotherapy decreased adrenaline levels and quantitatively influenced the natural killer cells and CD8+ cells, which express large amounts of β2-AR.
Journal
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- The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine
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The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 73 (2), 101-108, 2010
The Japanese Society of Balneology, Climatology and Physical Medicine
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Keywords
Details 詳細情報について
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- CRID
- 1390282681546936192
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- NII Article ID
- 10026515862
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- NII Book ID
- AN00186245
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- ISSN
- 18843697
- 00290343
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- NDL BIB ID
- 10591100
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL Search
- CiNii Articles
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- Abstract License Flag
- Disallowed