Ultrastructural Insights into Augmin-Dependent Microtubule Nucleation in the Spindle

DOI 21 References
  • Kamasaki Tomoko
    Division of Biological Science, Graduate School of Science, Nagoya University
  • Uehara Ryota
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo

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  • 紡錘体微小管の生成メカニズムに関する微細構造学的解析

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<p>The mitotic spindle is a highly organized microtubule-based structure that is required for accurate chromosome segregation. It is generally known that the centrosomes and the chromosomes function as scaffolds for microtubule generation during spindle formation. In addition, emerging evidence suggests that the microtubules within the spindle are important for the spindle microtubule supplementation.  An eight-subunit protein complex augmin plays a pivotal role in the microtubule-dependent microtubule generation during spindle formation, but the molecular basis of augmin’s functions remains unclear. Our latest research, which uses electron tomography and 3-D modeling, revealed that microtubule branching occurs within the spindle in an augmin-dependent fashion, demonstrating the ultrastructural basis of the microtubule-dependent microtubule generation during functional spindle formation.</p>

Journal

  • KENBIKYO

    KENBIKYO 48 (2), 90-93, 2013-08-30

    The Japanese Society of Microscopy

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