A Case of Acute Tubulointerstitial Nephritis after Oral Administration of Valacyclovir
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- SHINOHARA Hiromi
- Dept. of Pharmacy, Saku Central Hospital Advanced Care Center
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- ICHIKAWA Yuhei
- Dept. of Pharmacy, Saku Central Hospital Advanced Care Center
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- MURAKAMI Minoru
- Dept. of Nephrology, Saku Central Hospital
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- OSAWA Kousuke
- Dept. of Nephrology, Saku Central Hospital Advanced Care Center
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- SASAMOTO Itaru
- Dept. of Nephrology, Saku Central Hospital Advanced Care Center
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- HURUHATA Shunichi
- Dept. of Nephrology, Saku Central Hospital Advanced Care Center
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- SHIOZAWA Satoshi
- Dept. of Clinical Pathology, Saku Central Hospital Advanced Care Center
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- IKEZOE Masaya
- Dept. of Nephrology, Saku Central Hospital
Bibliographic Information
- Other Title
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- バラシクロビルにより急性尿細管間質性腎炎を発症した1例
- 症例報告 バラシクロビルにより急性尿細管間質性腎炎を発症した1例
- ショウレイ ホウコク バラシクロビル ニ ヨリ キュウセイ ニョウ サイカン カンシツセイジンエン オ ハッショウ シタ 1レイ
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Abstract
A woman in her 80s developed a feeling of abnormal sensation in her face and excessive salivation. She was diagnosed with right facial nerve paralysis and was admitted to a local hospital. On admission, serum creatinine level was 0.54mg/dL and estimated glomerular filtration rate was 79mL/min/1.73m2. She was started on oral valacyclovir at a dose of 3,000mg/day to treat the right facial nerve paralysis. However, 5 days after starting oral administration, she developed generalized fatigue, vertigo, and vomiting. Serum creatinine level rose to 4.99mg/dL with mild disturbance of consciousness, so she was transported to our hospital on suspicion of acyclovir-induced encephalopathy. We performed hemodialysis for 3 consecutive days to remove the acyclovir from the circulation, which subsequently improved all her symptoms. She was later diagnosed with allergic tubulointerstitial nephritis based on renal biopsy.After discharge from our hospital, laboratory data showed a serum creatinine level of 0.67mg/dL. We later confirmed that the serum acyclovir level before the first hemodialysis session had been very high (11.9μg/mL).
Journal
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- JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE
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JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE 68 (2), 180-184, 2019
THE JAPANESE ASSOCIATION OF RURAL MEDICINE
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Keywords
Details 詳細情報について
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- CRID
- 1390282752331572864
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- NII Article ID
- 130007715837
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- NII Book ID
- AN00196216
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- ISSN
- 13497421
- 04682513
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- NDL BIB ID
- 029957033
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed