Stigmatic imaging mass spectrometry using laser ionization

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  • レーザーイオン化を用いた投影型イメージング質量分析
  • レーザー イオンカ オ モチイタ トウエイガタ イメージング シツリョウ ブンセキ

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Abstract

<p>Imaging mass spectrometry (IMS) is an analytical technique to simultaneously obtain the spatial distributions of multiple atoms and molecules. Molecules such as lipids, proteins, and administered drugs in a biological tissue can comprehensively be observed without labeling. Higher spatial resolution and shorter measuring times compared to conventional scanning IMS are possible with stigmatic IMS, and its present status and future prospects are described. A spatial resolution of 1 μm for an artificial pattern has been shown with a stigmatic IMS device developed by the author and coworkers. Ion images of dyes obtained from a mouse cornea tissue stained with the dyes were matched to its optical photomicrograph. A semiconductor pixel ion detector MALPIX under development for stigmatic IMS is also introduced.</p>

Journal

  • Oyo Buturi

    Oyo Buturi 86 (5), 402-406, 2017-05-10

    The Japan Society of Applied Physics

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