Deoxyribonucleic acid sensor using electrolyte solution gate field effect transistors

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  • 電解質溶液ゲートFETを利用したDNAセンサー
  • デンカイシツ ヨウエキ ゲート FET オ リヨウシタ DNA センサー

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Abstract

<p>On a diamond surface, hydrogen-terminated, oxygen-terminated, fluorine-terminated, and the amine-terminated surfaces are separately fabricated. DNA is immobilized almost directly to the diamond surface by short linker binding to amine-terminated diamond surface. The oxygen-termination surface is negatively charged and repels DNA molecules, but provide a highly selective environment between complementary and single nucleotide polymorphism (SNPs). The charge difference between hybridization and denaturation is effectively reflected by the high surface Helmholtz capacitance formed between DNA and the surface channel. This is one of the major reasons why SNPs can be reproducibly detected by diamond field effect transistors.</p>

Journal

  • Oyo Buturi

    Oyo Buturi 77 (10), 1229-1234, 2008-10-10

    The Japan Society of Applied Physics

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