A Case of Merkel Cell Polyomavirus and CK20-negative Merkel Cell Carcinoma Complicated with Squamous Cell Carcinoma

TADA Mizuho, SONEZAKI Moe, SHONO Tomoko, ISHIKAWA Kazushi, NISHIDA Haruto, YOKOYAMA Shigeo, DAA Tsutomu, UEO Daisuke, HATANO Yutaka

doi:10.2336/nishinihonhifu.81.297

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有棘細胞癌を併発したメルケル細胞ポリオーマウイルスおよび CK20 陰性のメルケル細胞癌の 1 例
症例有棘細胞癌を併発したメルケル細胞ポリオーマウイルスおよびCK20陰性のメルケル細胞癌の1例
ショウレイユウキョクサイボウガンオヘイハツシタメルケルサイボウポリオーマウイルスオヨビ CK20 インセイノメルケルサイボウガンノ 1レイ

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<p>A 90-year-old woman was admitted to our hospital with a protruding tumor on her left cheek. The dome-shaped, reddish tumor was 2 cm in diameter. Tumor resection with a 1-cm side margin to the depth of the superficial muscular aponeurotic system (SMAS) was performed. Pathological examination revealed that the lesion infiltrated into the deep dermis and actually consisted of two lesions. One lesion consisted of atypical basophilic cells that were negative for CK20 but positive for nervous system tumor markers such as synaptophysin (SYP), chromogranin A (CGA), and CD56, leading to a diagnosis of Merkel cell carcinoma (MCC). The other lesion consisted of atypical squamous cells with eosinophilic cytoplasm and irregularly shaped nuclei, which were positive for CK5/6 but negative for CK20, SYP, CGA, and CD56, leading to a diagnosis of squamous cell carcinoma (SCC). The transitional areas of the two types of lesions were observed. All lesions were negative for Merkel cell polyomavirus (MCPyV) by immunohistochemical analysis. In the present and previously reported cases, MCPyV was negative in 15 of 16 lesions of MCC accompanied by SCC, suggesting that MCPyV is not involved in the carcinogenesis of MCC accompanied by SCC, and the mechanism of pathogenesis may be more complicated than that of MCPyV-positive MCC.</p>

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Nishi Nihon Hifuka

Nishi Nihon Hifuka 81 (4), 297-301, 2019-08-01

Western Division of Japanese Dermatological Association

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