A Case of Prepubertal Unilateral Fibrous Hyperplasia of the Labium Majus

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  • TANAKA Kayo
    Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University
  • NAGASE Kotaro
    Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University
  • NARISAWA Yutaka
    Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University

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Other Title
  • 思春期前の女児に生じた Prepubertal Unilateral Fibrous Hyperplasia of the Labium Majus の1例
  • 症例 思春期前の女児に生じたPrepubertal Unilateral Fibrous Hyperplasia of the Labium Majusの1例
  • ショウレイ シシュンキ マエ ノ ジョジ ニ ショウジタ Prepubertal Unilateral Fibrous Hyperplasia of the Labium Majus ノ 1レイ

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Description

<p>A 7-year-old girl presented with enlargement of the left labium majus without subjective symptoms. Histological examination of a biopsy specimen revealed proliferation of blood vessels, fibroblasts and collagen fibers. Immunohistochemically, the fibroblasts were positive for estrogen receptor but not progesterone receptor. She was diagnosed with prepubertal unilateral fibrous hyperplasia of the labium majus (PUFH). One year after diagnosis, there was no sign of growth or new lesions without any treatment. PUFH occurs in pre- and early pubertal girls and is characterized by painless, non-tender labial swelling. Only 42 cases of PUFH have been reported in the world so far and PUFH is a rare disease. PUFH is considered to be caused by the sex hormonal response. We report this case along with a literature review.</p>

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 81 (4), 293-296, 2019-08-01

    Western Division of Japanese Dermatological Association

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