Hepatopritective Limonoids from Andiroba (Carapa guianensis)
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- Morikawa Toshio
- 近畿大薬総研 近畿大アンチエイジングセ
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- Ninomiya Kiyofumi
- 近畿大薬総研 近畿大アンチエイジングセ
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- Ninomiya Kumi
- 近畿大薬総研
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- Marumoto Shinsuke
- 近畿大共同利用セ
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- Sakai Chie
- 近畿大薬総研
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- Miyazawa Seiya
- 近畿大薬総研
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- Ozeki Kaiten
- 近畿大薬総研
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- Matsuo Natsuko
- 近畿大薬総研
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- Muraoka Osamu
- 近畿大薬総研 近畿大アンチエイジングセ
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- Kikuchi Takashi
- 大阪薬大
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- Yamada Takeshi
- 大阪薬大
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- Tanaka Reiko
- 大阪薬大
Bibliographic Information
- Other Title
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- アンディローバ(Carapa guianensis)含有リモノイド成分の脂肪性肝炎抑制作用
Description
<p>Three gedunin-type limonoids, gedunin (1), 6a-acetoxygedunin (2), and 7-deacetoxy-7-oxogedunin (3), which were isolated from the seed and flower oils of andiroba (Carapa guianensis Aublet, Meliaceae), exhibited hepatoprotective effects at doses of 25 mg/kg, p.o. against D-galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. To characterize the mechanisms of action of 1–3 and clarify the structural requirements for their hepatoprotective effects, 17 related limonoids (1–17) isolated from the seed and/or flower oils of C. guianensis were examined inin vitro studies assessing their effects on (i) GalN-induced cytotoxicity in primary cultured mouse hepatocytes, (ii) LPS-induced nitric oxide (NO) production in mouse peritoneal macrophages, and (iii) tumor necrosis factor-a (TNF-a)-induced cytotoxicity in L929 cells. The mechanisms of action of 1–3 are likely to involve the inhibition of LPS-induced macrophage activation and reduced sensitivity of hepatocytes to TNF-a; however, these compounds did not decrease the cytotoxicity caused by GalN. In addition, the structural requirements of limonoids (1–17) for inhibition of LPS-induced NO production in mouse peritoneal macrophages and TNF-a-induced cytotoxicity in L929 cells were evaluated.</p>
Journal
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- Symposium on the Chemistry of Natural Products, symposium papers
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Symposium on the Chemistry of Natural Products, symposium papers 58 (0), Poster36-, 2016
Symposium on the Chemistry of Natural Products Steering Committee
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Details 詳細情報について
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- CRID
- 1390282752340957824
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- NII Article ID
- 130007722934
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- ISSN
- 24331856
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed