Hepatopritective Limonoids from Andiroba (Carapa guianensis)

DOI

Bibliographic Information

Other Title
  • アンディローバ（Carapa guianensis）含有リモノイド成分の脂肪性肝炎抑制作用

Abstract

<p>Three gedunin-type limonoids, gedunin (1), 6a-acetoxygedunin (2), and 7-deacetoxy-7-oxogedunin (3), which were isolated from the seed and flower oils of andiroba (Carapa guianensis Aublet, Meliaceae), exhibited hepatoprotective effects at doses of 25 mg/kg, p.o. against D-galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. To characterize the mechanisms of action of 1–3 and clarify the structural requirements for their hepatoprotective effects, 17 related limonoids (1–17) isolated from the seed and/or flower oils of C. guianensis were examined inin vitro studies assessing their effects on (i) GalN-induced cytotoxicity in primary cultured mouse hepatocytes, (ii) LPS-induced nitric oxide (NO) production in mouse peritoneal macrophages, and (iii) tumor necrosis factor-a (TNF-a)-induced cytotoxicity in L929 cells. The mechanisms of action of 1–3 are likely to involve the inhibition of LPS-induced macrophage activation and reduced sensitivity of hepatocytes to TNF-a; however, these compounds did not decrease the cytotoxicity caused by GalN. In addition, the structural requirements of limonoids (1–17) for inhibition of LPS-induced NO production in mouse peritoneal macrophages and TNF-a-induced cytotoxicity in L929 cells were evaluated.</p>

Journal

Details 詳細情報について

  • CRID
    1390282752340957824
  • NII Article ID
    130007722934
  • DOI
    10.24496/tennenyuki.58.0_poster36
  • ISSN
    24331856
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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