8.2.8　Effect of carbon ions on carcinogenesis

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  • Imaoka Tatsuhiko
    Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
  • Nishimura Mayumi
    Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
  • Daino Kazuhiro
    Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
  • Shimada Yoshiya
    Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
  • Kakinuma Shizuko
    Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology

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Other Title
  • 8.2.8　炭素線による発がん
  • 炭素線による発がん
  • タンソセン ニ ヨル ハツガン

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Abstract

<p>Heavy ion radiotherapy is expected to reduce the risk of second cancer by decreasing exposure of normal tissues to radiation. Emerging studies have attempted to predict the risk of second cancer after carbon ion radiotherapy based on dose assessment, the epidemiologically-identified risk of photon radiation, and assumptions about the relative biological effectiveness (RBE) of carbon ions. Nevertheless, large uncertainty remains in the choice of RBE of carbon ions in inducing cancer. The present article summarizes carcinogenesis experiments performed in animals using HIMAC. These animal experiments have yielded RBE values for selected tissues, beam types, and age at the time of irradiation. The results indicate potentially variable RBE which depends on tissues, ages, and dose levels. A few additional studies have attempted to identify molecular alterations in tumors induced by carbon ions. Thus, more comprehensive animal carcinogenesis studies are needed.</p>

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 68 (10), 741-748, 2019-10-15

    Japan Radioisotope Association

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