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Pneumonitis Due to <i>Oren-gedoku-to</i> (Coptis Detoxifying Decoction)

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  • Mochizuki Naoto
    Department of Respiratory Medicine, National Hospital Organization Kasumigaura Medical Center, Japan
  • Ano Satoshi
    Department of Respiratory Medicine, National Hospital Organization Kasumigaura Medical Center, Japan
  • Kikuchi Norihiro
    Department of Respiratory Medicine, National Hospital Organization Kasumigaura Medical Center, Japan
  • Sakai Chio
    Department of Respiratory Medicine, National Hospital Organization Kasumigaura Medical Center, Japan
  • Masuda Michiko
    Department of Respiratory Medicine, National Hospital Organization Kasumigaura Medical Center, Japan
  • Kondo Yuzuru
    Department of Diagnostic Pathology, National Hospital Organization Kasumigaura Medical Center, Japan
  • Ishii Yukio
    Department of Respiratory Medicine, National Hospital Organization Kasumigaura Medical Center, Japan Department of Respiratory Medicine, University of Tsukuba, Japan

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Abstract

<p>A 54-year-old man started to take oren-gedoku-to (coptis detoxifying decoction) because he was experiencing chronic hot flashes, night sweats and insomnia. He developed a high fever from the day of intake. At day 17, he stopped taking oren-gedoku-to because of malaise and chills, and he was admitted to our hospital. Drug-induced pneumonitis was suspected, and all drugs were stopped. Consequently, his symptoms, laboratory data and chest X-ray findings markedly improved. The results of a lymphocyte stimulation test were positive for oren-gedoku-to and one of its components, ougon (Baikal skullcap). Based on these findings, we diagnosed him with pneumonitis caused by ougon. </p>

Journal

  • Internal Medicine

    Internal Medicine 58 (20), 3019-3023, 2019-10-15

    The Japanese Society of Internal Medicine

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