The neuroinflammatory hypothesis of depression

DOI Web Site
  • Iwata Masaaki
    Division of Neuropsychiatry, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University

Bibliographic Information

Other Title
  • うつ病の炎症性神経障害仮説
  • ウツビョウ ノ エンショウセイ シンケイ ショウガイ カセツ

Search this article

Abstract

The neuroplasticity hypothesis is becoming more common in the pathology of depression, however the mechanisms by which stress causes atrophy of neuronal processes and decreases the synapse number is unknown. Here we showed that psychological stress is sensed by the innate immune system in the brain via NLRP3 inflammasome, which in turn releases pro-inflammatory cytokines. The NLRP3 inflammasome has become the focus of a wide range of medical research areas because it is a critical sensor for diverse diseases. Thus, it is critical for the development of new pharmacotherapeutic approaches that target neuro-inflammation in depression.

Journal

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top