Mouse behavioral indices for autism spectrum phenotypes

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  • Kakeyama Masaki
    Laboratory for Systems Neuroscience and Preventive Medicine, Waseda University Faculty of Human Sciences
  • Benner Seico
    Department of Child Psychiatry, The University of Tokyo Hospital
  • Fujiwara Masaya
    Laboratory for Systems Neuroscience and Preventive Medicine, Waseda University Faculty of Human Sciences

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Other Title
  • マウスにおける自閉スペクトラム発現の行動指標
  • マウス ニ オケル ジヘイスペクトラム ハツゲン ノ コウドウ シヒョウ

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We here review whether behavioral phenotypes and behavioral indices of mouse experiments can be extrapolated to human psychiatry or not. So far, social interaction tests and ultrasound utterances have been used as behavioral tests equivalent to disabilities in social communication and social interactions. Regarding the restricted and repetitive behaviors, the frequency of stereotypic movements and repetitive grooming behaviors, and the reversal task in T-maze and Morris water maze are commonly used. However, it is also pointed out that these are not necessarily ensured reproducibility and replicability. We also introduce new behavioral tests recently developed and discuss about the meaning of mouse model and mouse behavioral indices.

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