A case series of five patients with hepatic sarcoidosis diagnosed by liver biopsy
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- Sho Mitsuhiro
- Department of Hepatology, Graduate School of Medicine, Osaka City University Fujiidera Municipal Hospital
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- Enomoto Masaru
- Department of Hepatology, Graduate School of Medicine, Osaka City University
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- Kotani Kohei
- Department of Hepatology, Graduate School of Medicine, Osaka City University
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- Odagiri Naoshi
- Department of Hepatology, Graduate School of Medicine, Osaka City University
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- Yoshida Kanako
- Department of Hepatology, Graduate School of Medicine, Osaka City University
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- Motoyama Hiroyuki
- Department of Hepatology, Graduate School of Medicine, Osaka City University
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- Kozuka Ritsuzo
- Department of Hepatology, Graduate School of Medicine, Osaka City University
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- Fujii Hideki
- Department of Hepatology, Graduate School of Medicine, Osaka City University
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- Hagihara Atsushi
- Department of Hepatology, Graduate School of Medicine, Osaka City University
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- Uchida-Kobayashi Sawako
- Department of Hepatology, Graduate School of Medicine, Osaka City University
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- Morikawa Hiroyasu
- Department of Hepatology, Graduate School of Medicine, Osaka City University
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- Murakami Yoshiki
- Department of Hepatology, Graduate School of Medicine, Osaka City University
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- Tamori Akihiro
- Department of Hepatology, Graduate School of Medicine, Osaka City University
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- Kawada Norifumi
- Department of Hepatology, Graduate School of Medicine, Osaka City University
Bibliographic Information
- Other Title
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- 肝機能障害を契機に診断されたサルコイドーシス5例の検討
- カン キノウ ショウガイ オ ケイキ ニ シンダン サレタ サルコイドーシス 5レイ ノ ケントウ
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Abstract
<p>Sarcoidosis is typically characterized by the presence of lesions in the lungs, heart, eyes, and skin. However, in some cases, lesions have also been found in the liver. Although the diagnosis of hepatic sarcoidosis is difficult, liver biopsy can occasionally offer a definite diagnosis when blood test results indicate liver dysfunction of an unknown etiology. We encountered five cases of hepatic sarcoidosis at our hospital that were diagnosed based on liver dysfunction and compared these cases with previously reported cases. In our case series, hepatic sarcoidosis was predominantly diagnosed in middle-aged women, and biliary enzymes were elevated in most cases. Corticosteroids, ursodeoxycholic acid, or both were used for treatment. Despite the application of these therapies, some patients progressed to showing cirrhosis or even died. Thus, in cases with severe hepatitis, steroid therapy may not be effective and cirrhosis may develop. Moreover, the findings suggest that ursodeoxycholic acid can help in delaying the progression of hepatic sarcoidosis.</p>
Journal
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- Kanzo
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Kanzo 60 (11), 405-413, 2019-11-01
The Japan Society of Hepatology
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Keywords
Details 詳細情報について
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- CRID
- 1390282752358255616
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- NII Article ID
- 130007741895
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- NII Book ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- NDL BIB ID
- 030052419
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed