Clinical characteristics of young multiple myeloma patients: a single-center analysis of 30 patients

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  • YOSHIKI Yumiko
    Department of Hematology, Japanese Red Cross Medical Center
  • TSUKADA Nobuhiro
    Department of Hematology, Japanese Red Cross Medical Center
  • NASHIMOTO Junichiro
    Department of Hematology, Japanese Red Cross Medical Center
  • YOGO Takao
    Department of Hematology, Japanese Red Cross Medical Center
  • UTO Yui
    Department of Hematology, Japanese Red Cross Medical Center
  • SATO Kota
    Department of Hematology, Japanese Red Cross Medical Center
  • MIYAZAKI Kanji
    Department of Hematology, Japanese Red Cross Medical Center
  • OGURA Mizuki
    Department of Hematology, Japanese Red Cross Medical Center
  • ABE Yu
    Department of Hematology, Japanese Red Cross Medical Center
  • OKAZUKA Kiyoshi
    Department of Hematology, Japanese Red Cross Medical Center
  • ISHIDA Tadao
    Department of Hematology, Japanese Red Cross Medical Center
  • SUZUKI Kenshi
    Department of Hematology, Japanese Red Cross Medical Center

Bibliographic Information

Other Title
  • 単一施設における若年骨髄腫30例の検証
  • 臨床研究 単一施設における若年骨髄腫30例の検証
  • リンショウ ケンキュウ タンイツ シセツ ニ オケル ジャクネン コツズイシュ 30レイ ノ ケンショウ

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Description

<p>Because multiple myeloma is rare in young people, there are fewer reports on the same. Thus, its clinical aspects and prognosis remain unelucidated. We retrospectively evaluated 30 patients with multiple myeloma aged ≤ 45 years at diagnosis. We divided them into three groups based on their cytogenetic risks: standard risk (SR), high risk (HR), and unknown risk. The frequency of HR patients was 36.6%, the highest of the three groups, unlike the previous report. The median progression-free survival (PFS) was 35 months (SR vs. HR, 46 vs. 29 months), and the median overall survival (OS) was not reached (NR) (SR vs. HR, NR vs. 82 months). The OS was significantly worse, and the PFS also appeared inferior in HR patients. The International Staging System score was not associated with OS. Thus, young patients with myeloma appeared to have a higher frequency of HR features, suggesting that instead of age, the cytogenetic risk was a significant prognostic factor.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 60 (10), 1411-1417, 2019

    The Japanese Society of Hematology

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