Novel Technology of Nano-Porous Drug Particles by Using Unique Spray Nozzle

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  • OZEKI Tetsuya
    Graduate School of Pharmaceutical Sciences, Nagoya City University

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  • 特殊な噴霧ノズルによるナノ多孔性薬物微粒子製造技術

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<p>We have been preparing nanocomposite particle which is microparticle containing drug nanoparticles by using 2-solution mixing type spray nozzle. The two passages (carrier-based aqueous solution & organic solution of poorly water-soluble drug) are used in the spray drying equipped with 2-solution mixing type spray nozzle. In the nozzle, the drug solution was mixed with aqueous solution and the drug nano-core is produced by changing the solubility of drug (i.e. anti-solvent effect). Before the drug is crystallized completely, the solution is spray-dried, and drug-nanocomposite particles are obtained. Down-sizing of drug particle is useful method to increase the surface area of drug particle, resulting in the improvement of drug dissolution. Additionally, the 2-solution mixing type spray nozzle is useful in the point of cost and productivity. In this study, in order to extend the application of 2-solution type nozzle, the nano-matrix microparticle was prepared. Sodium chloride-based nano-matrix microparticle was prepared successfully. The nano-porous microparticle has light property and has large void in microparticles. So, this is useful for the inhalation formulation. Eventually, the sodium chloride-based nano-matrix microparticle is promising inhalation against cystic fibrosis.</p>

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