Cytotoxicity of Synthesized 1,4-Naphthoquinone Oxime Derivatives on Selected Human Cancer Cell Lines
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- Zhang Qijing
- School of Pharmacy, Shanghai Jiao Tong University
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- Dong Jinyun
- School of Pharmacy, Shanghai Jiao Tong University
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- Cui Jiahua
- School of Pharmacy, Shanghai Jiao Tong University
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- Huang Guang
- School of Pharmacy, Shanghai Jiao Tong University
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- Meng Qingqing
- School of Pharmacy, Shanghai Jiao Tong University
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- Li Shaoshun
- School of Pharmacy, Shanghai Jiao Tong University
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説明
<p>In an effort to develop potent and selective antitumor agents, a series of 1,4-naphthoquinone oxime derivatives were designed and synthesized. The cytotoxicity of these compounds were evaluated against five human cancer cell lines (colorectal cancer cell: HCT-15, breast cancer cell: MDA-MB-231, liver cancer cell: BEL-7402, colorectal cancer cell: HCT-116 and ovarian cancer cell: A2780) in vitro. Among them, compound 14 was found to be the most potent cytotoxic compound against three cell lines (MDA-MB-231, BEL-7402 and A2780) with IC50 values of 0.66±0.05, 5.11±0.12 and 8.26±0.22 µM, respectively. Additionally, the length of the side chains and the position of the substituent may also affect the cytotoxic activity of the naphthoquinone oxime derivatives. In general, compound 14 effectively inhibited breast cancer cell proliferation and may become a promising anticancer agent.</p>
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 66 (6), 612-619, 2018-06-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282763013477504
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- NII論文ID
- 130007382330
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 029007021
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- PubMed
- 29863062
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
