Relative examination with lung capacity compartmentation and ALS functional rating scale in the amyotrophic lateral sclerosis

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  • Yasuda Masayo
    Department of Clinical Laboratory, National Hospital Organization Kumamoto Minami National Hospital
  • Kurisaki Ryoichi
    Department of Neurology, National Hospital Organization Kumamoto Minami National Hospital Department of Neurology, National Hospital Organization Kumamoto Saisyunsou National Hospital
  • Honda Fumi
    Department of Clinical Laboratory, National Hospital Organization Kumamoto Minami National Hospital
  • Higashihara Etsuko
    Department of Clinical Laboratory, National Hospital Organization Kumamoto Minami National Hospital
  • Sakamoto Tetsuro
    Department of Neurology, National Hospital Organization Kumamoto Minami National Hospital
  • Nakahara Keiichi
    Department of Neurology, National Hospital Organization Kumamoto Minami National Hospital Department of Neurology, Graduate School of Medical Sciences, Kumamoto University
  • Uekawa Kazutoshi
    Department of Neurology, National Hospital Organization Kumamoto Minami National Hospital

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  • 筋萎縮性側索硬化症における肺気量分画とALS機能評価スケールとの関連性の検討

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Abstract

<p>Background : In patients with amyotrophic lateral sclerosis (ALS), various guidelines recommend to perform a diachronic pulmonary function test. Furthermore, we pay attention to the usefulness of measuring the vital capacity as percent of predicted (%VC), in addition to measuring the forced vital capacity as percent of predicted (%FVC) at our institute.</p><p>Methods : We measured VC and FVC every month. We also examined bulbar paralysis, physical function, and respiratory function based on the ALS usability test scale and their association with %VC and %FVC in 18 patients with ALS. Furthermore, we analyzed the correlation between the spare expiratory reserve volume, inspiratory capacity, and ALSFRS–R total score.</p><p>Results : For each ALSFRS–R item, physical function and bulbar paralysis correlated with %FVC and %VC ; however, respiratory function did not correlate with them. In patients with ALS, the diachronic pulmonary function test was useful for estimating physical function and bulbar paralysis. In addition, the inspiratory component of the pulmonary function test correlated with the ALSFRS–R total score.</p><p>Conclusion : Multidimensional evaluation of the pulmonary function test is important during follow–up for patients with ALS.</p>

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