An application of Doehlert matrix optimization on developing of flow injection analysis of neomycin in pharmaceutical samples
書誌事項
- タイトル別名
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- Original Paper
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説明
This work proposes a Flow Injection Analysis (FIA) system to determine neomycin in pharmaceutical formulation, utilizing ninhydrin as chromogenic reagent, with absorbance signal measured at 570 nm. To check the significant flow parameters, a screening with 24 full factorial designs was optimized, and a Doehlert matrix used to obtain the optimum variable values. The method presents two linear responses ranging from 29.8 up to 300 mg L-1 (r2=0.9933) and 800.0 up to 2500 mg L-1 (r2=0.9926). The Limits of Detection and Quantifications were 8.94 mg L-1 and 29.8 mg L-1, respectively. The readings frequency was of 33 reading h-1. The method accuracy was checked through comparison with HPLC method and the results found were similar (t-test, 95% confidence level). The method was applied in pharmaceutical samples with very good performance and the precision (RSD) was always below 8.0%. The reagent and sample consumption was very low, what is in agreement with the green chemistry concept.
収録刊行物
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- FIA研究懇談会会誌
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FIA研究懇談会会誌 31 (2), 107-, 2014
公益社団法人 日本分析化学会 フローインジェクション分析研究懇談会
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詳細情報 詳細情報について
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- CRID
- 1390282763014214144
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- NII論文ID
- 130007395795
- 40020411673
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- NII書誌ID
- AA10962565
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- ISSN
- 24337374
- 0911775X
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- NDL書誌ID
- 026281866
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可