The Development of a Novel Diagnostic Assay That Utilizes a Pseudotyped Vesicular Stomatitis Virus for the Detection of Neutralizing Activity against Crimean-Congo Hemorrhagic Fever Virus
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- Suda Yuto
- Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases
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- Chamberlain John
- National Infection Service, Public Health England
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- Dowall Stuart D.
- National Infection Service, Public Health England
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- Saijo Masayuki
- Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases
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- Horimoto Taisuke
- Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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- Hewson Roger
- National Infection Service, Public Health England
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- Shimojima Masayuki
- Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases
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Abstract
<p>Crimean-Congo hemorrhagic fever virus is a risk group 4 pathogen, which mandates the use of maximum containment facilities, often termed biosafety level 4 or containment level 4 when working with infectious materials. Diagnostic and research work involving live viruses in such laboratories is time-consuming and inconvenient, resulting in delays. Herein, we show that serum neutralizing activity against the virus can be measured in low-containment laboratories using a pseudotyped virus.</p>
Journal
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 71 (3), 205-208, 2018
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
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Details 詳細情報について
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- CRID
- 1390282763014488320
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- NII Article ID
- 130006743921
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- NII Book ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL BIB ID
- 029009474
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- PubMed
- 29709967
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed