First Identification of Human Adenovirus 57 (HAdV-57) in Japan

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  • Tatsumi Chika
    Shimane Prefectural Institute of Public Health and Environmental Science
  • Iizuka Setsuko
    Shimane Prefectural Institute of Public Health and Environmental Science
  • Mita Tetsuo
    Shimane Prefectural Institute of Public Health and Environmental Science Shimane Prefectural Laboratory of Meat Hygiene Inspection Station
  • Wada Mieko
    Shimane Prefectural Institute of Public Health and Environmental Science Shimane Prefectural Medical Affairs and Public Health Division
  • Hanaoka Nozomu
    Infectious Disease Surveillance Center, National Institute of Infectious Diseases
  • Fujimoto Tsuguto
    Infectious Disease Surveillance Center, National Institute of Infectious Diseases

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<p>Neutralization tests have been routinely used for the identification of human adenovirus C species (HAdV-C) in Japan until 2007. The aim of this study was to clarify the serological cross-reactivity of antiserum that has been used exclusively in Japan and to describe the first identification of HAdV type 57 (HAdV-57) in Japan. Anti-HAdV serum to HAdV-1, 2, 5, and 6 was quantitatively evaluated for cross-reactivity to the HAdV-57 isolates. Anti-HAdV-6 serum neutralized HAdV-57 with a concentration that was 32 to 64-fold higher than what was necessary to neutralize homologous HAdV-6. HAdV-1, 2, and 5 strains were not neutralized by anti HAdV-6 serum. Furthermore, 28 HAdV-6 strains isolated from 6,476 clinical samples were re-examined for HAdVs detected in the Shimane Prefecture of Japan from 2005 to 2014. These 28 strains were re-examined by PCR-sequencing techniques using the penton, hexon, and fiber regions. 3 isolates were determined to be HAdV-57. These data show that HAdV-57 had already invaded Japan as early as 2005, and that HAdV-57 strains were misidentified as HAdV-6.</p>

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